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Author's name: Samayyy

Guide, Weight Loss

Tesamorelin: the approved GHRH analogue for visceral fat

Tesamorelin is a synthetic analog of GHRH (Growth Hormone-Releasing Hormone) with a prolonged half-life, approved by the FDA under the name Egrifta for visceral lipoatrophy. Its precise mechanism of action on the GH/IGF-1 axis and its robust clinical data make it a reference compound for research on visceral adipose metabolism.

Longevity, Science

NAD+: sirtuins, DNA repair, and strategies to restore its levels

Nicotinamide adenine dinucleotide (NAD+) is central to hundreds of metabolic reactions. Its cellular levels decline by approximately 50% between the ages of 20 and 60, correlating with mitochondrial decline, loss of DNA repair capacity, and sirtuin depletion. Understanding the biochemistry of NAD+ is essential for evaluating restoration strategies: NMN, NR, and direct injections.

Longevity, Science

MOTS-c: the mitochondrial peptide that mimics exercise

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA type-c) is a 16-amino-acid micropeptide encoded by mitochondrial DNA—a major 2015 discovery that revolutionized our understanding of mitochondrial signaling. It activates the AMPK pathway, enhances insulin sensitivity, and produces exercise-like effects in preclinical models.

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