Le Retatrutide 10mg (research code LY3437943, also known as GLP-3) is a next-generation triagonist peptide developed by Eli Lilly. It simultaneously activates three key metabolic receptors: GLP-1 (glucagon-like peptide-1), GIP (glucose-dependent insulinotropic polypeptide) and the receptor at glucagonThis triple synergistic action makes it one of the most studied peptides in research on obesity and metabolic disorders.
Mechanism of action
The simultaneous activation of GLP-1, GIP, and glucagon produces complementary effects: GLP-1 reduces appetite and slows gastric emptying; GIP improves insulin sensitivity and potentiates the action of GLP-1; glucagon increases energy expenditure and stimulates hepatic lipolysis. This metabolic convergence is reflected, in clinical studies, by a body weight reduction of up to 24% in 48 weeks (Phase 2 data, NEJM 2023).
10mg format — for whom?
The 10mg format is recommended for initial research protocols or for gradual dose titration. It allows for a graded approach by increasing weekly doses in 2mg increments, minimizing the risk of gastrointestinal side effects. This format offers the best mg/€ ratio for a first experience with Retatrutide.
Technical specifications
- HPLC Purity ≥99% certified by Janoshik Analytical (accredited independent laboratory)
- Certificate of Analysis (COA) available per production batch
- Freeze-dried form — maximum stability at -20°C for 24 months
- Reconstitution with bacteriostatic water (0.9% benzyl alcohol)
- Molecular weight: 4,730.46 g/mol — Formula: C₂₁₀H₃₃₃N₅₁O₆₁
Storage and replenishment
Store the lyophilized vial at -20°C before reconstitution. After reconstitution with 1 to 2 mL of bacteriostatic water, the solution is stable for 4 weeks at +4°C. Avoid repeated freeze/thaw cycles. Handle under aseptic conditions for laboratory research.
Shipping and tracking
Each batch is traceable from freeze-drying to shipping. Discreet packaging within 48-72 hours to all of Europe (France, Belgium, Germany, Spain, Italy, Netherlands, Poland, Portugal). Secure SEPA bank transfer. This product is intended exclusively for scientific research.
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