Le Retatrutide 20mg (LY3437943, GLP-3) is the high-dose form of the reference triagonist peptide in metabolic research. By simultaneously activating the receptors GLP-1, GIP et glucagonIt is the most powerful agent currently available in its class for studying the mechanisms of weight loss and metabolic regulation.
Results of clinical trials
The Phase 2 clinical trial data published in the New England Journal of Medicine (Jastreboff et al., 2023) show a average reduction in body weight of 17.5% to 24.2% based on the dosage over 48 weeks — significantly outperforming Semaglutide (~15%) and Tirzepatide (~22%) at equivalent doses. Retatrutide is currently in Phase 3 clinical trials.
Triple agonist mechanism
The mechanism of action is based on three axes: (1) agonism GLP-1 reduces appetite via hypothalamic centers and slows gastric emptying; (2) agonism GIP improves insulin sensitivity and potentiates glucose-dependent insulin secretion; (3) agonism glucagon It increases thermogenesis, basal energy expenditure, and stimulates hepatic lipolysis. This triple convergence explains the superiority observed compared to mono- and dual-agonists.
20mg format — for intensive protocols
The 20mg format is suitable for advanced research protocols requiring higher doses or longer durations. It allows for the high doses (8mg-12mg/week) used in Phase 2 clinical trials to be achieved with a reduced number of vials. Recommended for experienced researchers who have already used the 10mg format.
Technical specifications
- HPLC Purity ≥99% certified by Janoshik Analytical
- Batch Certificate of Analysis (COA) — full traceability
- Freeze-dried form — stability 24 months to -20°C
- Recommended reconstitution: 2 mL of bacteriostatic water
- Peptide sequence: acylated analog of GIP with structural modifications GLP-1/glucagon
Storage and handling
Unreconstituted lyophilized solution: stable for 24 months at -20°C. Reconstituted solution: stable for 4 weeks at +4°C, protected from light. Handle under aseptic conditions. Avoid freezing the reconstituted solution. This product is intended for scientific research use only.
Shipping to Europe
Discreet shipping within 48-72 hours to France, Belgium, Luxembourg, Germany, Spain, Italy, the Netherlands, Poland, and Portugal. Secure packaging, temperature controlled. SEPA transfer or card accepted.
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