Le GHK-Cu 50mg (Glycyl-L-Histidyl-L-Lysine Copper) is an endogenous tripeptide naturally present in human plasma, saliva, and urine. Discovered by Loren Pickart in 1973, it is one of the most studied copper peptides in the scientific literature for its tissue regeneration, gene modulation, and antioxidant protection properties.
Molecular mechanism of action
GHK-Cu acts via several molecular pathways: (1) copper chelation — the peptide-Cu²⁺ complex facilitates intracellular copper transport, an essential cofactor of antioxidant enzymes (SOD, ceruloplasmin); (2) fibroblast activation — stimulates the synthesis of collagen types I, III and IV, elastin and glycosaminoglycans; (3) epigenetic modulation — studies show the activation of more than 4,000 genes involved in tissue repair and the inhibition of pro-inflammatory genes.
Documented search applications
- Skin and dermis : increased dermal thickness, wrinkle reduction, stimulation of collagen production (in vitro and in vivo studies)
- Hair follicles : stimulation of hair growth, enlargement of follicles, inhibition of local 5-α-reductase
- Healing : accelerated wound closure, reduction of hypertrophic scars, stimulation of angiogenesis
- Neural protection : documented neuroprotective effects via modulation of the BDNF factor
- Systemic anti-inflammatory : inhibition of TNF-α, reduction of chronic inflammation markers
Technical specifications
- HPLC Purity ≥99% certified by Janoshik Analytical
- Molecular formula: C₁₄H₂₄CuN₆O₄ — Molecular weight: 403.90 g/mol
- Freeze-dried form — stability 24 months to -20°C
- Solubility: very good in water (>50 mg/mL)
- Certificate of Analysis (COA) available per batch
Reconstitution and storage
Reconstitute with sterile or bacteriostatic water. The reconstituted solution (recommended concentration: 5–10 mg/mL) is stable for 4 weeks at +4°C, protected from light. The lyophilized powder can be stored for up to 24 months at -20°C. GHK-Cu is sensitive to oxidants—avoid prolonged contact with air after reconstitution.
Shipping
Discreet shipping within 48-72 hours throughout Europe. Insulated packaging. This product is intended exclusively for scientific research.
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