Le NAD+ 100mg Nicotinamide adenine dinucleotide (NAD) is an essential coenzyme involved in over 500 enzymatic reactions in human cells. Central to mitochondrial energy metabolism and the regulation of longevity enzymes (sirtuins, PARP), it is the subject of intensive research on cellular aging, neuroprotection, and metabolic recovery.
Fundamental biological role
NAD+ is an essential cofactor of the mitochondrial respiratory chain (complexes I to IV) and the Krebs cycle. Its cellular levels naturally decline with age—up to 50% discount for those between 40 and 60 years old according to several studies. This depletion is associated with mitochondrial dysfunction, cognitive decline, and increased susceptibility to metabolic diseases.
Main research avenues
- Sirtuines (SIRT1-7) NAD+ is the obligatory substrate of sirtuins, NAD+-dependent deacetylases involved in epigenetic regulation, DNA repair, and mitochondrial biogenesis.
- PARP1/2 : DNA repair enzymes that consume NAD+, activated by double-strand breaks
- CD38/CD157 NAD+ consuming glycohydrolases, overexpressed with age — target for preserving NAD+ levels
- Tryptophan metabolism Kynurenine pathway — endogenous biosynthesis of NAD+ from dietary tryptophan
Technical specifications
- Purity ≥99% — oxidized form (NAD⁺), not reduced
- Molecular formula: C₂₁H₂₇N₇O₁₄P₂ — Molecular weight: 663.43 g/mol
- Freeze-dried form — hygroscopic, to be kept sealed -20°C
- Aqueous solubility: excellent (>100 mg/mL)
- Certificate of Analysis (COA) per production batch
Storage and handling
NAD+ is sensitive to humidity and heat. Store at -20°C in a dry atmosphere. After reconstitution, use within 24 hours or aliquot and refreeze immediately. Do not expose to extreme pH levels (unstable in alkaline environments). Handle with gloves to avoid enzymatic contamination.
Shipping
Discreet shipping within 48-72 hours throughout Europe. Thermally protected packaging. Product intended exclusively for scientific research.
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