Le Brenipatide 1mg(LY3537031) is a next-generation peptide designed asdual agonist of GIP and GLP-1 receptorsDesigned with a profile geared towards central nervous system applications, it co-activates two incretin pathways for synergistic effects on satiety, metabolism, and reward circuits. Its low-dose format (1 mg) reflects its potency and long duration of action.
Molecular mechanism of action
Brenipatide acts via the co-activation of two incretin receptors: (1)GLP-1R agonism— stimulates glucose-dependent insulin secretion, slows gastric emptying and promotes satiety; (2)GIP-R agonism— potentiates the insulin response and improves glucose sensitivity; (3)incretin synergy— co-activation produces effects on appetite and energy expenditure that are greater than those of a single receptor agonism; (4)central action— GLP-1 receptors in the CNS modulate reward circuits and eating behavior; (5)long-lasting action— prolonged pharmacokinetic profile suitable for spaced administration.
Search applications
- Carbohydrate metabolism and insulin sensitivity
- Regulation of appetite and satiety
- Energy expenditure and body composition
- CNS reward circuits and addictive behaviors (research)
- Research on obesity and metabolic syndrome
- Study of GIP/GLP-1 incretin pathways
Analytical data
- Identifier:LY3537031 (dual GIP/GLP-1 agonist)
- HPLC Purity:≥99% (Janoshik certified, COA available per batch)
- Shape :White, sterile lyophilized powder
- Solubility:Bacteriostatic water, sterile water, physiological saline solution
- Freeze-dried powder storage:Up to 24 months at -20°C
- Reconstituted storage:4 weeks at +4°C, away from light
Reconstitution & Storage
Reconstitute with sterile or bacteriostatic water. The reconstituted solution is stable for 4 weeks at +4°C, protected from light. The unreconstituted lyophilized powder can be stored for up to 24 months at -20°C. Avoid repeated freeze-thaw cycles and prolonged contact with air after reconstitution.
Shipping
Discreet shipping within 48-72 hours to all of Europe (France, Belgium, Germany, Spain, Italy, Netherlands, Poland, Portugal). Insulated packaging. Full traceability from freeze-drying to delivery. Payment via secure SEPA bank transfer. This product is intended exclusively for scientific research.
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